Where are our Forth processors, our object processors, like those Lisp and SmallTalk processors with gc and type affordances in hardware, our clockless asynchronous processors, our Transmeta-like fluid lines between hardware and software, between microcode and ISA-targeted machine code, etc.
How weird do our high-level languages need to be to benefit from an exotic CPU?
JavaScript and even more so Python are embarrassingly non-weird, so imperative and linear that they trip up anything that wants any assurances, but my go-to expectation is that functional languages might do cool stuff with immutability, upfront data dependencies etc. And packages within meh languages might do cool stuff, like pandas and numpy within Python.