Conversation

Notices

1. Don Romano 🍹 (thj@mastodon.cloud)'s status on Sunday, 21-Jul-2019 06:59:30 EDT Don Romano 🍹

   In case anyone wants it, here's a pharmacokinetic model I made of instant-release Ritalin.

   The ramp-up is modelled using the generalised logistic function and the taper-off is modelled using a biexponential function.

   At first, I was confused by the fact that I was unable to fit an ordinary exponential function to the point set, but then I looked around a little, and that's when I learned that they often use biexponential functions in such models.

   1. Don Romano 🍹 (thj@mastodon.cloud)'s status on Sunday, 21-Jul-2019 07:15:07 EDT Don Romano 🍹

      in reply to

      Now, I could've continued to use point set I was using before, with interpolation to smooth it out, but this has one major drawback:

      You can't do algebra and calculus on a point set. You need equations.

      One equation I'm trying to work out is one that, given a y value from the biexponential function b(t) in the picture above, gives me the value for t.

      This would be useful for calculating the timing of doses instead of guessing or hand tuning them like I'm doing right now.