As for replies: They don't work very well.
Firstly, the original post isn't propagated across the network to everyone the reply is propagated to, leaving the reply dangling without context for many people.
Secondly, it's not always evident in the timeline feed whether a post is a reply or just a mention, and if you want to check that, you will have to expand it, and due to the issue above, proceed to view the thread on the originating instance.
That's just not what people do.